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ea0076p3 | Abstracts | CHD2021

Enhanced expression of the proinflammatory, profibrotic molecule, vascular adhesion protein-1 in carcinoid heart disease valves

Sagar V.M. , Neil D.A.H. , Liu B. , Barriuso J. , Manoharan P. , Patten D.A. , Lamarca A. , Valle J.W. , Steeds R.P. , Shah T. , Shetty S. , Weston C.J.

Introduction Vascular adhesion protein-1 (VAP-1) is a known driver of hepatic inflammation and fibrosis, with elevated levels detected in the circulation in disease. We studied the tissue expression of VAP-1 in midgut NETs and carcinoid heart disease (CHD) alongside circulating soluble VAP-1 (sVAP-1) to determine the role of VAP-1 in NETs.Methods Expression of VAP-1 and inflammatory and stromal markers in midgut NETs tissue, CHD valves and control valves...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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